Metric vs ME?
Depends where you are coming from and what you want or need to do…
Nearly all of my new machinery, jig, tool-builds etc use metric fasteners – and I've standardised on M6/M8 for my clamping devices (regardless of T-slot size). Metric fasteners are generally cheaper and easier to get hold of.
However, for my model work, I've stuck with BA and ME sizes – because I already have the tools and a good inventory of fittings collected over the years. I've no good reason to want to migrate now and my models were all built using them.
I also own old British & American machine tools – so they need non-metric fasteners for any repair or maintenance.
There is also one other reason to use older, imperial threads. There is a great deal of good quality, imperial sized tooling still available at reasonable cost if you need it – versus a lot of sometimes questionable metric 'new' tooling.
I've just purchased a full set of 3/8ths taps, plus matching die for a job – and they are good quality British HSS tools that will last me out. Why? Well I needed L/H threads – and couldn't find metric near equivalents that I wanted to afford….
So generally, yes going metric makes sense – but there are also good reasons not to…at least for me.
Regards,
IanT