Nick;
I'm almost 100% metricated, but somethings (e.g., SS balls, some materials, etc) are still in inches, at least on my side of the Atlantic.
I'm working on TWO locomotives; (don't ask) one has plans in inches, the other in MM. The one in inches has pencil marks on drawings indicating what the dimensions in MM are.
For screws, I just look and decide what is the most appropriate (BA to MM, thread pitches, etc)
The plans are, in general, just a "rough idea" anyways, so once you start, and think about things that MUST be standard (such as track gauge) you'll figure it out.
(if you ask; once the current locomotive projects are complete, anything following will have plans fully in metric, at least that's what I'm saying now. There are other issues other than inches/mm; all the metric plans I have are much better than ANY of the inch-based ones, with one exception – Kozo Hiraoka designed the Heisler in inches, to appease criticism, I'd guess)