As a non loco man, without any first hand knowledge, the problem with all locos seems to be having the crankpins truly at right angle to each other, at the same radius, and the coupling rod centres exactly the same as the axle box centres. When everything coincides, superb, when there is a slight discrepancy; problems.
And that ignores the effects of expansion as things warm up!
In UK the Great Western Railway used optical alignment and worked to close tolerances. The horn guides were ground on both sides of the frames at the same setting.Their locos were quiet and efficient. Unlike some other railway's locos, it was very tare to hear one "clank" as it moved, even in wartime. One GWR man is reputed to have said "We scrap at the sizes where others assemble"
Hope that you get everything sorted out and have a really potent loco.
Howard