Transfer one, once that's drilled & threaded you can bolt it up and do the others using the clearance holes as a guide. Mill accuracy will be perfectly adequate, as you say location is provided by the register.
Once mounted, use a known-good object (shank of a fat, unused end mill?) and DTI to check run-out at the jaws. I have one of those chucks, the original 'set-up' pinion wasn't marked, you will probably find that you get wildly differing results depending which pinion you use to tighten down the work. Mark the one that gives best results.
Once you have done that, rotate the chuck about the mounting holes on the backplate, you may find a particular position will give an improved result.
I think it's a good choice, I wasn't that impressed with the 'feel' when I first had mine, but a bit of 'a wire-brush' deburr & some use, and it's improved markedly, repeatable run-out in the less-than-half-thou to one thou range depending on how fussy one wants to be setting the work.
Occasionally EK10 soft jaws turn up on sale at decent prices – well worth getting a set.
Edited By DiogenesII on 05/02/2021 15:41:57