Usually not a functional issue when scaling up but its wise to keep an eye on the strength / stiffness aspects of components. At smaller sizes components often have to be thicker or of larger than "scale" size to ensure that they are not too floppy to function well. The fixings and screw sizes used are often relatively oversize too so that ordinary range threads etc. can be used rather than the super weeny watchmakers versions.
By reason of familiarity such relative over-sizes can be seen as perfectly acceptable on a very small model but if carried over onto something rather larger ( i.e small model) the effect can be jarringly wrong. I've no idea where the line between very small and small falls but I'm sure we have all seen examples of nice work being wasted because such things ensure that it will never look right.
Clive
PS Neil types faster!
Edited By Clive Foster on 15/02/2013 21:26:26