Thanks everyone for you ideas and suggestions. A cobalt drill was the answer. Once I had got through the surface and drilled a pilot it was fairly straightforward to open it up using HSS bits in a mains drill and low speed. As mentioned by Colin, breaking through was a bit of a struggle. It also tapped OK. There were no glass-hard patches but it was much harder than the other castings on the mill that I have drilled previously. Anyway, thanks to the forum problem solved, now to finish tramming.
The cobalt drills are revelation, I had never used them before. A bought a couple from Toolstation, they were as cheap as chips. Why don't we use them all the time, maybe others do!