I'd do them separately using the DRO to set out the holes. Spot and clearance size in one plate. Spot and tapping size in the other and while it's on the mill use that to also guide the tap perfectly perpendicular
Missed the edit, if I did not know the hole ctrs then use a spotting drill if I have one that fits existing hole if not use a drill bit of the same size to transfer onto the undrilled material.
Edited By JasonB on 11/02/2022 12:58:09