There will be a relationship between 1.25mm, 2.5mm and 5mm pitch.
Try one of the other two and see if the thread produced bears the same relationship to the 4.5mm pitch as when attempting 1.25mm.
If the results are consistent, something is wrong with the setup you have chosen (perhaps because you have misinterpreted the instructions). In particular, have you set lever 3 for metric?
Please link to the manual you have so we can all read and hopefully come to the same conclusion. The one I see only uses the 42t gear as a driver in position C/A for 4mm, 5mm and 6mm metric pitches. It says that 36 pitches can be cut using the 21t driver, but the remaining 9 (at the coarser end) need the larger driver. This makes logical sense. It does not make sense to use a large driving gear for a fine pitch thread.
You would find further assistance on the Colchester group at groups.io