As a general guideline, when designing machine parts, I leave at least one material thickness, preferably two material thicknesses, between tapdrill hole edge and plate edge. Of course this isn't always possible, and if not, a quick stress analysis calculation is a good idea if forces or loads involved are high.
I'm sure others will say I'm dead wrong, but the approach has worked for me in industry for 30 years.
JD
Edited By Jeff Dayman on 13/08/2014 10:38:44