Nige,
Why design your own? There are plenty of working designs out there already and yours will likely mirror one of those already existing – or maybe a combination of several. Some are better than others and yours may well not be as good as the best out there.
Make your own, by all means, but my advice is to choose a design which is proven to work (popular reiews) and get on with it.
I would be using easily purchased, good quality, reliable wheels from a good supplier. Making those as “few offs” is neither cost effective nor easy. Replacing, or adding, wheels later would be simple – and a lot less hassle than making your own to exacting standards.
Your choice in the end, of course, but that is what I would suggest. Re-inventing the wheel has been done umpteen times, but few have bettered the basic age old design of a circular rim running on an axle!