David,
What gauge are you looking at? What is the loco?
My advice, much like Neils, would be to find a local foundry or one someone can recommend that are happy to work with 3D printed patterns. Take along a sketch or drawing and show them what you have in mind and take on board their advice.
The main things they will advise on is how the pattern needs to be made, whether its a 2 part pattern if you have tapered spokes both sides or single piece on a simpler pattern and what sort of shrinkage is required and lastly where they would want to add their runners too. Don't forget your own machining allowances too!
With regards to having a pattern made for sand casting I have found a place in London called 3D print UK to be very good. They use Nylon and offer a free polishing surface to give a great surface finish.
If you are looking at small gauge locos, for one offs 3D wax printing and investment cast iron could be a better route/cost effective route and experience in this so far has had brilliant results on cast iron wheels.
Hope that helps,
Adam