I'm just getting into the use of my GH Universal. The largest cuts I've taken so far are 3 x 6mm in mild steel (making tee nuts), using a 12mm end mill at 600 RPM, cutting dry and with 2-in-1 oil. I also get some rumbling from the headstock with these cuts, which disappears again with finishing cuts.
The end mill has been previously used quite a bit on aluminium and once on gauge plate. The gauge plate was significantly harder going than mild steel. The teeth don't look blunter but the surface finish is affected on cuts taken after the gauge plate. The gears do become a bit quieter after some running in. Keeping the jibs tight on non-moving axes, plus a bit on the sliding one, helps.
I have experience in using industrial mills, so the 'machine talks to me', and I adjust hand feed, etc., accordingly. The feed doesn't want to be too low, enough to load the cutter, but for those unaccustomed to machine tools, this is not woodwork!
Bill