Some years ago I turned down the flow temperature on my combi boiler, an experiment based purely on having read how they worked and figuring that the efficiency of the condensing feature should improve the lower the temperature of the returning water is.
I was surprised how well it worked, with a considerable reduction in gas consumption. What I hadn’t expected was that it actually improves the perceived comfort – the boiler runs for longer so that rather than giving a burst of heat and then turning off, so the temperature in the room starts to fall which gives a perception of increasing chilliness, the air temperature remains much more constant removing the temptation to bump the thermostat up a bit to recover the previous comfort level.
This means that you may be able to reduce the temperature setting, saving even more.
I don’t know whether the boiler life is affected by running continuously, though at a lower output – since I rent, I don’t really care, but the boiler hasn’t given any trouble, despite the gas inspector being rather sniffy about the manufacturer – “I’m surprised that thing’s still working, they’re the cheapest load of old junk you can get”.