I quite liked having my lathe at 45 degrees to the wall after years of it sitting against the back wall. I think it may have made slightly better use of the floor space but I suspect the benefit was mainly that it broke up the otherwise rather unimaginative, rectilinear layout. It also freed up valuable wall space.
One of the most useful machines in my workshop has always been the engine crane. As different fads have taken a grip of me, I have moved stuff about to give better acces to the gear I will use most, including the Bantam and the Bridgeport. That flexibility is probably more valuable to me than trying to find the definitive layout. Besides, you should always be planning on more acquisitions. You can figure out how to fit them all in later…
Murray