On my S7 I have marked one of the two possible engagements of the little flick lever which gives the solid drive rather than back gear, so I always ensure it is only engaged in this one position. Hence when the spindle lock is engaged, my headstock spindle is always in a certain orientation. Having engaged the spindle lock, and properly fitted a chuck, I have then drilled a little dimple in each and every headstock spindle-mounted chuck such that the dimple points upwards. These dimples are painted black. Hence I can easily spin the chuck to rotate the headstock spindle more or less the correct orientation to engage the spindle lock.
Having engaged the spindle lock, each chuck was unscrewed very carefully until it just disengaged with the thread. Another dimple was drilled in each chuck at the vertical position at the point of disengagement and the dimple filled with red paint. Hence I know when the chuck is about to unscrew – or it has one more full turn to make – so I can take hold of it before it unexpectedly releases and smashes down on to the lathe bed. Also I can orient the chuck correctly to start it on the spindle threads (with the spindle lock engaged) so that again, it engages immediately and doesn't fall off when I release my grip on it.
I did the same thing with my ML7 years ago but I dimpled the spindle so I could orientate that correctly for chuck-changing as above.
I did this because I did something similar with M42 screw-mount lenses many years ago when I dropped a 400mm lens on to some concrete due to it not being in the correct orientation to start engaging the threads.
The spindle lock is provided for a purpose – use it and don't end up with a dentally-challenged lathe and a stupid expression on your face.