At the risk of being accused of stating the bleeding obvious, a 4-flute, end-cutting cutter is like a four-facet twist drill, but with a couple of extra cutting edges. So, if you can sharpen twist drills with four facets – or, better still, as split-points – you can sharpen these cutters. The extra two cutting edges will be conveniently out of the way, provided that the central arris is not normal to the 'long' cutting edges, as in Andrew Johnston's right-hand pic, and not as in Jason B's 'Rougher'. Nothing wrong with the latter, but far harder to set up successfully.