"To key or not to key" pops up regularly on here.
The instruction that we were given as Apprentices was "NEVER"
The proof of that is as I walked past another Apprentice using a Slitting saw, there was a sound like breaking glass, and bits started flying around the shop!
Fortunately for me, I didn't stop any of them.
He had used a key, and the saw had jammed.
Without a key, a jammed saw will slip.
With a key, the key will split the saw, leading, possibly to injury or damage.
Having a left hand thread, you could mount the saw the other way up and reverse the spindle. That would tighten the clamp nut. But DON'T use a key if you value your health.
Howard