Of course it is possible. Just that one would need to convert the metric requirements to imperial measurements if one wanted to use the scales on the machine slides. One can measure a length (or any other dimension, for that matter) in any chosen units. It is internationally accepted to use S.I. units these days. Only the USA and a very few other places continue with non-metricated units – but there are a lot of lathes, etc, still around with imperial scales, and quite a lot of the older generations still stuck with the old system (even personal height, weight measurements by younger people who don't actually learn the feet, inches, stones, pounds and ounce systems at school!)
It is interesting to note that final sizing is normally measured by a separate instrument (micrometer) and these are at the choice of the user. Even if using a dro, measurements of items produced will still be checked at least occasionally by micrometer, etc.
One good reason for modellers, making items faithfully to scale, is that the orignal '12" to the foot' models were all made in imperial units in the UK, and there are easily scaled (in the main) to 1/2, 1/3, 1/4, 1/6 of the original.
Even the american system is usually worked in thousandths of an inch, even if they start out a 1/4, 1/8, 1/16, 1/32, 1/64 etc!