Hi Martin
Ream the holes first.
Make a test bar and turn it down slightly bigger than the reamed holes. Put a shallow taper on the end of the bar, and poking it into the reamed holes you can see how far you are away from a dead fit in he holes.
Carefully skim the test bar until its a tight push fit in the wheels and note the cross–slide reading.
Use this setting to turn the ends of the axles for loctiting, or if you want a press fit, leave them slightly oversize.
Don't pay any attention to suggestions of leaving space for the loctite, it works best when the two surfaces have a shearing fit and a pin tight in a hole is what its designed to work with, though it will forgive you if you make the axles slightly undersize.
Neil