Primary advantage of the larger screw is that it will be somewhat stiffer. Probably noticeably so on a change wheel machine with the extra length between bearings where the gearbox goes. Whether that makes any real world difference, stiff enough is stiff enough after all, is a whole n'other thing.
Most likely disadvantage is discovering the hard way that there were small changes in component size, shape and position made to accommodate the larger screw. Big changes are easily seen but essentially invisible changes like that often involve components being shifted by a few tens of thou with accompanying changes in size to turn a shoehorn job into something with proper fitment room and engineering clearances. If you have both sizes og bearing maybe a bit of careful measurement, maybe a mock up too, might be in order. Half nut operating co-axila and central on the leadscrew would be my big worry. Small adjustments there look like being a complete PIA.
Clive.