You would have (up to) 6 different drill bits.
For example;
A componet may have a particular hole feature that is drilled through, threaded and have two additional counterbores. In this instance four of the six pillars would be set up as such.
Pillar 1 – Drill through
Pillar 2 – Deepest counterbore
Pillar 3 – Shallowest couterbore.
Pillar 4 – A tap to thread the hole via a self reversing tapping attachment mounted in the drilling machine.
A single operator would have the componet in a 'jig' and move it to each pillar 1-4 sequentially to complete that operation. On completion, the componet is removed from the jig, a new undrilled componet clamped in the jig and you drill the new componet as before. Before CNC this was how 'mass production' drilling operations were performed.
I hope this helps
Alan.